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Doctor's profiles

Michihiro Iwashiro, D.D.S, Ph.D

s_michihiro (1)

Graduated School of Dentistry, Nagasaki University

Worked at Suzuki Dental Clinic
Studied about Immunology at Kyoto University Faculty of Medicine

Worked at Kyoto University Hospital

Worked at Ijinnkai Takeda Hospital

Worked at Rocky Mountain Laboratories, National Institute of Health as visiting fellow

Worked at Tango Furusato Hospital 

Worked at Kasagi oral dental clinic as a chief director
Worked at Kyoto University Hospital once a week

Contract teacher at Nihon University Dental School at Matsudo

Contract teacher at Tohoku University

Contract teacher at Kinki University Medical School, Immunology


Member of Japanese Society of Oral and Maxillofacial Surgeons
Member of Japan Geriatric Society
Member of International Association of Oral and Maxillofacial Surgeons
Director of Non-profit organization of Water Fluoridation Fund (NPO-WFF)

Publications in English

20: Antunes I, Tolaini M, Kissenpfennig A, Iwashiro M, Kuribayashi K, Malissen B, Hasenkrug K, Kassiotis G. Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. Immunity. 2008 Nov;29(5):782-94

19: Dittmer U, He H, Messer RJ, Schimmer S, Olbrich AR, Ohlen C, Greenberg PD, Stromnes IM, Iwashiro M, Sakaguchi S, Evans LH, Peterson KE, Yang G, Hasenkrug KJ. Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection. Immunity. 2004 Mar;20(3):293-303.

18: Iwashiro M, Wang Jinyan, Toda M, Wang Linan, Kato T, Kuribayashi K. Effective anti-tumor adoptive immunotherapy: utilization of exogenous IL-2-independent cytotoxic T lymphcyte clones. Int. Immunol. 2002 Vol. 14(12): 1459-1468

17: Iwashiro M, Messer RJ, Peterson K, Stromnes IM, Sugie T, Hasenkrug KJ. Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc. Natioal. Acad. Sci. USA 2001 July; 98(16): 9226-9230.

16: Iwashiro M, Peterson K, Messer RJ, Stromnes IM, Hasenkrug KJ. CD4(+) T cells and gamma interferon in the long-term control of persistent friend retrovirus infection. J Virol. 2001 Jan;75(1):52-60.

15: Peterson KE, Iwashiro M, Hasenkrug KJ, Chesebro B. Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia. J Virol. 2000 Jun;74(11):5363-7.

14: Kondo T, Uenishi H, Shimizu T, Hirama T, Iwashiro M, Kuribayashi K, Tamamura H, Fujii N, Fujisawa R, Miyazawa M, et al. A single retroviral gag precursor signal peptide recognized by FBL-3 tumor-specific cytotoxic T lymphocytes. J Virol. 1995 Nov;69(11):6735-41.

13: Kakimi K, Kuribayashi K, Iwashiro M, Masuda T, Sakai M, Ling W, Kubo Y, Kobayashi H, Higo K, Seki M, et al. Hepatitis C virus core region: helper T cell epitopes recognized by BALB/c and C57BL/6 mice. J Gen Virol. 1995 May;76 ( Pt 5):1205-14.

12: Kitajima T, Iwashiro M, Kuribayashi K, Imamura S. Effect of parent genetic background on latency and antigenicity of UV-induced tumors originating in F1 hybrids. Exp Dermatol. 1995 Feb;4(1):42-5.

11: Shimizu T, Uenishi H, Teramura Y, Iwashiro M, Kuribayashi K, Tamamura H, Fujii N, Yamagishi H. Fine structure of a virus-encoded helper T-cell epitope expressed on FBL-3 tumor cells. J Virol. 1994 Dec;68(12):7704-8.

10: Kitajima T, Iwashiro M, Kuribayashi K, Imamura S. Immunological characterization of tumor-rejection antigens on ultraviolet-light-induced tumors originating in the CB6F1 mouse. Cancer Immunol Immunother. 1994 Jun;38(6):372-8.

9: Kitajima T, Iwashiro M, Kuribayashi K, Imamura S. The role of CD4+ and CD8+ cells in normal F1 hybrid host in the resistance to lethal graft-versus-host disease induction by transfer of parent spleen cells. Immunol Lett. 1994 Jun;40(3):207-10.

8: Morioka A, Iwashiro M, Matsubayashi Y, Teramura Y, Kuribayashi K. Effects of non-MHC background genes on the induction of CD4+ T cells that prevent rejection of a highly immunogenic tumor, FBL-3. Int Immunol. 1994 Jun;6(6):839-46.

7: Suzuki M, Iwashiro M, Takatsuki F, Kuribayashi K, Hamuro J. Reconstitution of anti-tumor effects of lentinan in nude mice: roles of delayed-type hypersensitivity reaction triggered by CD4-positive T cell clone in the infiltration of effector cells into tumor. Jpn J Cancer Res. 1994 Apr;85(4):409-17.

6: Nakagawa Y, Kakimi K, Ling W, Kubo Y, Higo K, Masuda T, Kuribayashi K, Iwashiro M, Komatz Y, Hirama T, et al. Inhibition of murine AIDS (MAIDS), development by the transplantation of bone marrow cells carrying the Fv-4 resistance gene to MAIDS virus-infected mice. J Virol. 1994 Mar;68(3):1438-41.

5: Iwashiro M, Kondo T, Shimizu T, Yamagishi H, Takahashi K, Matsubayashi Y, Masuda T, Otaka A, Fujii N, Ishimoto A, et al. Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells. J Virol. 1993 Aug;67(8):4533-42.

4: Kubo Y, Nakagawa Y, Kakimi K, Matsui H, Iwashiro M, Kuribayashi K, Masuda T, Hiai H, Hirama T, Yanagawa S, et al. Presence of transplantable T-lymphoid cells in C57BL/6 mice infected with murine AIDS virus. J Virol. 1992 Sep;66(9):5691-5.

3: Hirama T, Takeshita S, Matsubayashi Y, Iwashiro M, Masuda T, Kuribayashi K, Yoshida Y, Yamagishi H. Protein, Nucleotide Conserved V(D)J junctional sequence of cross-reactive cytotoxic T cell receptor idiotype and the effect of a single amino acid substitution. Eur J Immunol. 1991 Feb;21(2):483-8.

2: Matsubayashi Y, Hirama T, Morioka A, Iwashiro M, Masuda T, Uchino H, Takeshita S, Yamagishi H, Udono H, Mieno M, et al. Participation of a dominant cytotoxic T cell population defined by a monoclonal antibody in syngeneic anti-tumor responses. Eur J Immunol. 1990 Sep;20(9):2095-103.

1: Matsubayashi Y, Zenita K, Morioka A, Iwashiro M, Masuda T, Uchino H, Fujita T, Kuribayashi K. Characterization of a CD4(L3T4)-positive cytotoxic T cell clone that is restricted by class I major histocompatibility complex antigen on FBL-3 tumor cell. Immunobiology. 1989 Nov;180(1):33-46.

Dr. Kiyo Iwashiro


Graduated School of Dentistry, Shouwa University

Worked at Osaka dental college hospital

Worked at Periodontics P. Clinic as a dental assistance

Worked at D H M Center in Japan

Worked at Kasagi Oral and Dental Clinic as a medical staff


Worked at Kasagi Oral and Dental Clinic at Minamiyamashiromura as a chief

Japanese Society of Periodontology
Japanese Academy of Clinical Periodontology
Japanese Society fo Disphagia Rehabilitation
Japanese Society of Oral and Maxillofacial Radiology

A certificated dentist of oral radiology

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